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Phenotypes Associated with This Genotype
Genotype
MGI:4830996
Allelic
Composition		 Gt(ROSA)26Sortm1(NOTCH3)Sat/Gt(ROSA)26Sor+
Notch3Gt(PST033)Byg/Notch3Gt(PST033)Byg
Tg(Tagln-cre)1Her/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(NOTCH3)Sat mutation (1 available); any Gt(ROSA)26Sor mutation (1060 available)
Notch3Gt(PST033)Byg mutation (0 available); any Notch3 mutation (96 available)
Tg(Tagln-cre)1Her mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased cerebral infarct size ( J:133358 )
• following filament middle cerebral artery occlusion, mice exhibit reduced infarct volume compared with similarly treated Notch3Gt(PST033)Byg homozygotes

nervous system
decreased cerebral infarct size ( J:133358 )
• following filament middle cerebral artery occlusion, mice exhibit reduced infarct volume compared with similarly treated Notch3Gt(PST033)Byg homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory