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Phenotypes Associated with This Genotype
Genotype
MGI:4829677
Allelic
Composition		 Tnfaip3tm1.1Gvl/Tnfaip3tm1.1Gvl
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Tg(Vil1-cre)997Gum/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Vil1-cre)997Gum mutation (2 available)
Tnfaip3tm1.1Gvl mutation (0 available); any Tnfaip3 mutation (43 available)
Tnfrsf1atm1Mak mutation (2 available); any Tnfrsf1a mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
decreased susceptibility to induced colitis ( J:163410 )
• mice exhibit decreased susceptibility compared to Tnfrsf1atm1Mak/Tnfrf1+ Tnfaip3tm1.1Gvl Tg(Vil-cre)997Gum mice
increased susceptibility to induced colitis ( J:163410 )
• mice exhibit increased susceptibility compared to in Tnfrsf1atm1Mak homozygotes

immune system
decreased susceptibility to induced colitis ( J:163410 )
• mice exhibit decreased susceptibility compared to Tnfrsf1atm1Mak/Tnfrf1+ Tnfaip3tm1.1Gvl Tg(Vil-cre)997Gum mice
increased susceptibility to induced colitis ( J:163410 )
• mice exhibit increased susceptibility compared to in Tnfrsf1atm1Mak homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/28/2024
MGI 6.13 		The Jackson Laboratory