Phenotypes Associated with This Genotype

Genotype
MGI:4821751

• Allelic Composition: Gata3^tm3Gsv/Gata3^tm3Gsv; Tg(Dbh-icre)1Gsc/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal embryo development ( J:163233 )

nervous system

abnormal sympathetic ganglion morphology ( J:163233 )

• decreased cell proliferation is observed at E11. and E12.5 (to 36 and 20% of controls respectively)

• levels of apoptotic cells is significantly increased at E11.5 and E13.5

• sympathetic ganglion size is reduced in area between E10.5 and 16.5 (3-fold decrease in area in contrast to 20-fold increase in size in controls)

• chromaffin cell numbers are decreased to <10% of those in controls at E13.5 (number of apoptotic chromaffin cells is strongly increased by E15.5); however, chromaffin cells in the adrenal glands are not affected

abnormal nervous system development ( J:163233 )

• at E13.5, area of cells expressing the autonomic lineage marker Phox2b and noradrenergic and neuronal markers is reduced to <10% of that in controls