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Phenotypes Associated with This Genotype
Genotype
MGI:4821387
Allelic
Composition		 Prnptm1Cwe/Prnptm1Cwe
Tg(Prnp)C4Cwe/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm1Cwe mutation (37 available); any Prnp mutation (143 available)
Tg(Prnp)C4Cwe mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased brain copper level ( J:126728 )
• after 12 months, copper levels in the brain fail to increase with age unlike in wild-type mice
• copper levels in the synaptosomes are decreased compared to in wild-type mice

nervous system
decreased brain copper level ( J:126728 )
• after 12 months, copper levels in the brain fail to increase with age unlike in wild-type mice
• copper levels in the synaptosomes are decreased compared to in wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory