Phenotypes Associated with This Genotype

Genotype
MGI:4819238

• Allelic Composition: Irf1^tm1Mak/Irf1^tm1Mak; Trp53^tm1Sia/Trp53^tm1Sia
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased tumor-free survival time ( J:55418 )

• earlier tumor induced death

neoplasm

increased tumor incidence ( J:55418 )

• 96% develop tumors by 299 days of age compared to 56% of mice only homozygous for Trp53^tm1Sia

• greater frequency of multiple tumors

increased lymphoma incidence ( J:55418 )

increased hemangiosarcoma incidence ( J:55418 )

• angiosarcoma

increased teratoma incidence ( J:55418 )

• immature teratomas