About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:4461060
Allelic
Composition
Igh-Jtm1Aigl/Igh-J+
Mogtm1Dpd/Mogtm1Dpd
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic
Background
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1Aigl mutation (0 available); any Igh-J mutation (11 available)
Mogtm1Dpd mutation (0 available); any Mog mutation (47 available)
Tg(Tcra2D2,Tcrb2D2)1Kuch mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• disease started between 7 and 10 weeks of age, with classical paralytic EAE signs

muscle
• in a minority of cases, with a spastic component

nervous system
• inflammatory infiltrates in the trigeminal ganglia, spinal ganglia, spinal roots despite the absence of MOG within these tissues
• inflammatory infiltrates in the peripheral nervous system despite the absence of MOG within these tissues
• lesions consisting of lymphocytic infiltration, demyelation and axonal damage in optic nerve
• lesions consisting of lymphocytic infiltration, demyelation and axonal damage in the spinal cord
• within the spinal cord and optic nerve

vision/eye
• lesions consisting of lymphocytic infiltration, demyelation and axonal damage in optic nerve

immune system
• inflammatory infiltrates in the trigeminal ganglia, spinal ganglia, spinal roots despite the absence of MOG within these tissues

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
multiple sclerosis DOID:2377 OMIM:126200
OMIM:612594
OMIM:612595
OMIM:612596
OMIM:614810
J:151335


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
03/21/2017
MGI 6.08
The Jackson Laboratory