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Phenotypes Associated with This Genotype
Genotype
MGI:4460266
Allelic
Composition
Msh2tm2.1Rak/Msh2tm2.1Rak
Tg(Vil-cre)20Syr/0
Genetic
Background
involves: 129/Sv * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh2tm2.1Rak mutation (1 available); any Msh2 mutation (62 available)
Tg(Vil-cre)20Syr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• 89% of mice develop small intestine tumors compared with 6% of wild-type mice
• 50% of small intestine tumors are adenomas while the rest are highly invasive adenocarcinomas
• 50% of small intestine tumors are highly invasive adenocarcinomas
• 50% of small intestine tumors are adenomas

mortality/aging
• all mice die by 17 months of age

neoplasm
• 89% of mice develop small intestine tumors compared with 6% of wild-type mice
• 50% of small intestine tumors are adenomas while the rest are highly invasive adenocarcinomas
• 50% of small intestine tumors are highly invasive adenocarcinomas
• 50% of small intestine tumors are adenomas
• in only 1 of 150 mice

homeostasis/metabolism
• intestinal epithelial cells exhibit an increase in microsatellite instability compared with wild-type cells
• tumor cells exhibit increased microsatellite instability compared with wild-type cells

cellular
• intestinal epithelial cells exhibit an increase in microsatellite instability compared with wild-type cells
• tumor cells exhibit increased microsatellite instability compared with wild-type cells

Mouse Models of Human Disease
OMIM ID Ref(s)
Lynch Syndrome I 120435 J:161577


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory