Mouse Genome Informatics
cn
    Msh2tm2.1Rak/Msh2tm2.1Rak
Tg(Vil-cre)20Syr/0

involves: 129/Sv * C57BL/6 * FVB/N * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• all mice die by 17 months of age

tumorigenesis
• in only 1 of 150 mice
• 89% of mice develop small intestine tumors compared with 6% of wild-type mice
• 50% of small intestine tumors are adenomas while the rest are highly invasive adenocarcinomas
• 50% of small intestine tumors are adenomas
• 50% of small intestine tumors are highly invasive adenocarcinomas

homeostasis/metabolism
• intestinal epithelial cells exhibit an increase in microsatellite instability compared with wild-type cells
• tumor cells exhibit increased microsatellite instability compared with wild-type cells

cellular
• intestinal epithelial cells exhibit an increase in microsatellite instability compared with wild-type cells
• tumor cells exhibit increased microsatellite instability compared with wild-type cells

Mouse Models of Human Disease
OMIM IDRef(s)
Lynch Syndrome I 120435 J:161577