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Phenotypes Associated with This Genotype
Genotype
MGI:4460234
Allelic
Composition
Il10tm1Cgn/Il10tm1Cgn
Nos2tm1Lau/Nos2tm1Lau
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il10tm1Cgn mutation (15 available); any Il10 mutation (43 available)
Nos2tm1Lau mutation (8 available); any Nos2 mutation (67 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• 120% more necrosis after experimental ischemia and reperfusion than found in controls
• 72% more polymorphonuclear neutrophiles per unit area in mid-ventricular slices relative to controls

homeostasis/metabolism
• 120% more necrosis after experimental ischemia and reperfusion than found in controls
• 72% more polymorphonuclear neutrophiles per unit area in mid-ventricular slices relative to controls


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory