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Phenotypes Associated with This Genotype
Genotype
MGI:4458210
Allelic
Composition		 Tcf3tm1(TCF3/HLF)Homy/Tcf3+
Tg(Emu-Zfp521)1Homy/0
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf3tm1(TCF3/HLF)Homy mutation (0 available); any Tcf3 mutation (48 available)
Tg(Emu-Zfp521)1Homy mutation (1 available)
Tg(Mx1-cre)1Cgn mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:160392 )
• within 6 months, pIpC-treated mice die of leukemia

neoplasm
increased leukemia incidence ( J:160392 )
• pIpC-treated mice develop acute B-lineage leukemia by 6 months of age unlike control mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory