Analysis Tools
cellular
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• after 10 weeks, mice exhibit goblet cell depletion in the colon unlike in wild-type mice
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• following PMA and ionomycin stimulation, B cells exhibit an increased percentage of B cells in the S phase and fewer in G2 phase compared with similarly treated wild-type cells
• LPS-stimulated B cells exhibit an increase in percentage of cells in the S phase compared with similarly treated wild-type cells
• however, proximal mitogenic signaling and cell cycle entry are normal
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• B cells fail to proliferate after BCR stimulation, or treatment with the diacylglycerol mimetic, PMA, and the Ca++ mobilizing agent ionomycin unlike similarly treated wild-type mice
• however, B cell stimulated with LPS or CD40 exhibit normal proliferation
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mortality/aging
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• mice die by 14 weeks of age
(J:160090)
• however, adoptive transfer of wild-type splenocytes reduces early mortality and adoptive transfer of Cd4, Cd8a, or Tcra-J null splenocytes prevents premature death
(J:160090)
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immune system
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• by 14 weeks, mice exhibit intestinal inflammation unlike wild-type mice
• treatment with antibiotics ameliorates intestinal inflammation
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• after 6 weeks, mice exhibit cell infiltration of the colon unlike wild-type mice
• after 10 weeks, mice exhibit severe colitis with goblet cell depletion, leukocyte infiltration into the lamina propria, epithelial cell hyperplasia, and crypt loss unlike wild-type mice
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• mice exhibit thymus atrophy with age unlike wild-type mice
• however, adoptive transfer of wild-type splenocytes rescues thymus atrophy
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• mice exhibit an increase in granulocyte numbers in the spleen compared with wild-type mice
• however, antibiotic treatment prevents accumulation of granulocytes
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• mice exhibit lymphopenia unlike wild-type mice
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• splenic B cells are decreased in number compared to in wild-type mice
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• the number of mature B cell in the B cell compartment is reduced compared to in wild-type mice
• however, the percentages of marginal zone B cells and follicular B cells are normal
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• near absent
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• near absent
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• the number of invariant NK T cells is reduced with age unlike in wild-type mice
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• reduced in size and number by P14 with granulocyte accumulation
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• mice immunized with NP-CGG+alum+LPS or NP-ficoll fail to produce T-dependent antigen-specific IgG1 antibodies or T-independent antigen-specific IgM responses unlike similarly treated wild-type mice
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• following PMA and ionomycin stimulation, B cells exhibit an increased percentage of B cells in the S phase and fewer in G2 phase compared with similarly treated wild-type cells
• LPS-stimulated B cells exhibit an increase in percentage of cells in the S phase compared with similarly treated wild-type cells
• however, proximal mitogenic signaling and cell cycle entry are normal
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• B cells fail to proliferate after BCR stimulation, or treatment with the diacylglycerol mimetic, PMA, and the Ca++ mobilizing agent ionomycin unlike similarly treated wild-type mice
• however, B cell stimulated with LPS or CD40 exhibit normal proliferation
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• mice exhibit a trend towards reduced Ig2a serum levels compared with wild-type mice
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• alpha-Gal-Cer-stimulated invariant NK T cells produce no IFN-gamma and TNF-alpha and reduced IL4 compared with wild-type mice
• however, alpha-Gal-Cer-stimulated invariant NK T cells produce normal amounts of IL13
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• following alpha-Gal-Cer stimulation
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• following alpha-Gal-Cer stimulation
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• in alpha-Gal-Cer-stimulated invariant NK T cells
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• in alpha-Gal-Cer-stimulated invariant NK T cells
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• in alpha-Gal-Cer-stimulated invariant NK T cells
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• mice immunized with ovalbumin-expressing cells fail to reject adoptively transferred NK cells or CD8+ T cell target cells unlike similarly treated wild-type mice
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digestive/alimentary system
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• after 10 weeks, mice exhibit epithelial cell hyperplasia in the colon unlike in wild-type mice
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• after 10 weeks, mice exhibit crypt loss in the colon unlike in wild-type mice
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• after 10 weeks, mice exhibit goblet cell depletion in the colon unlike in wild-type mice
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• by 14 weeks, mice exhibit intestinal inflammation unlike wild-type mice
• treatment with antibiotics ameliorates intestinal inflammation
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• after 6 weeks, mice exhibit cell infiltration of the colon unlike wild-type mice
• after 10 weeks, mice exhibit severe colitis with goblet cell depletion, leukocyte infiltration into the lamina propria, epithelial cell hyperplasia, and crypt loss unlike wild-type mice
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liver/biliary system
| N |
• in culture, hepatocytes show no growth advantage and no dysplastic liver cells are observed
• mice exhibit normal liver metabolic function
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• mice exhibit extramedullary hematopoiesis in the liver with foci of hematopoietic cells and hyperplastic nodules unlike wild-type mice
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growth/size/body
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• by 14 weeks, mice exhibit wasting unlike wild-type mice
(J:160090)
• however, mice treated with antibiotics or adoptive transfer of wild-type, Cd4, Cd8a, or Tcra-J null splenocytes do not exhibit weight loss
(J:160090)
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• after 4 weeks in male mice
• after 6 weeks in female mice, less dramatic than in male mice
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homeostasis/metabolism
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• following alpha-Gal-Cer stimulation
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• following alpha-Gal-Cer stimulation
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endocrine/exocrine glands
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• after 10 weeks, mice exhibit crypt loss in the colon unlike in wild-type mice
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• after 10 weeks, mice exhibit goblet cell depletion in the colon unlike in wild-type mice
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• mice exhibit thymus atrophy with age unlike wild-type mice
• however, adoptive transfer of wild-type splenocytes rescues thymus atrophy
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hematopoietic system
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• mice exhibit thymus atrophy with age unlike wild-type mice
• however, adoptive transfer of wild-type splenocytes rescues thymus atrophy
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• mice exhibit extramedullary hematopoiesis in the liver unlike in wild-type mice
• however, adoptive transfer of wild-type splenocytes reduces extramedullary hematopoiesis
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• mice exhibit normocytic anemia unlike wild-type mice
• however, adoptive transfer of wild-type splenocytes rescues anemia
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• the number of megakaryocyte/erythroid progenitors in the bone marrow decline with age unlike in wild-type mice
• the numbers of megakaryocyte/erythroid and granulo-monocyte progenitors are increased in the liver compared to in wild-type mice
• however, the number of common lymphoid progenitors in the bone marrow is normal
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• mice exhibit an increase in common myeloid progenitors (CMP) in the liver compared with wild-type mice
• however, adoptive transfer of wild-type splenocytes reduces splenic CMPs
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• mice exhibit an increase in common lymphocyte progenitors (CLP) in the liver compared with wild-type mice
• however, adoptive transfer of wild-type splenocytes reduces splenic CLPs
• however, the number of common lymphoid progenitors in the bone marrow is normal
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• mice exhibit an increase in granulocyte numbers in the spleen compared with wild-type mice
• however, antibiotic treatment prevents accumulation of granulocytes
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• mice exhibit lymphopenia unlike wild-type mice
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• splenic B cells are decreased in number compared to in wild-type mice
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• the number of mature B cell in the B cell compartment is reduced compared to in wild-type mice
• however, the percentages of marginal zone B cells and follicular B cells are normal
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• near absent
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• near absent
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• the number of invariant NK T cells is reduced with age unlike in wild-type mice
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• hematopoietic stem cells and hematopoietic precursors remained in the adult liver unlike in wild-type mice
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• reduced in size and number by P14 with granulocyte accumulation
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• mice immunized with NP-CGG+alum+LPS or NP-ficoll fail to produce T-dependent antigen-specific IgG1 antibodies or T-independent antigen-specific IgM responses unlike similarly treated wild-type mice
|
|
• following PMA and ionomycin stimulation, B cells exhibit an increased percentage of B cells in the S phase and fewer in G2 phase compared with similarly treated wild-type cells
• LPS-stimulated B cells exhibit an increase in percentage of cells in the S phase compared with similarly treated wild-type cells
• however, proximal mitogenic signaling and cell cycle entry are normal
|
|
• B cells fail to proliferate after BCR stimulation, or treatment with the diacylglycerol mimetic, PMA, and the Ca++ mobilizing agent ionomycin unlike similarly treated wild-type mice
• however, B cell stimulated with LPS or CD40 exhibit normal proliferation
|
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• mice exhibit a trend towards reduced Ig2a serum levels compared with wild-type mice
|
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• alpha-Gal-Cer-stimulated invariant NK T cells produce no IFN-gamma and TNF-alpha and reduced IL4 compared with wild-type mice
• however, alpha-Gal-Cer-stimulated invariant NK T cells produce normal amounts of IL13
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