Gimap5^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Gimap5^m1Btlr
• Name: GTPase, IMAP family member 5; mutation 1, Bruce Beutler
• MGI ID: MGI:4456885
• Synonyms: Gimap5^sph, Gimap5^sphx, sphinx
• Gene: Gimap5 Location: Chr6:48723131-48731134 bp, + strand Genetic Position: Chr6, 23.71 cM
• Alliance: Gimap5^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a G to T transition that results in the amino acid substitution of cysteine for glycine at position 38 (G38C). The absence of protein expression was confirmed by western blot analysis on total bone marrow cells and spleen B cells. (J:160090)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gimap5 Mutation: 13 strains or lines available

References

• Original: J:160090 Barnes MJ, et al., Loss of T cell and B cell quiescence precedes the onset of microbial flora-dependent wasting disease and intestinal inflammation in Gimap5-deficient mice. J Immunol. 2010 Apr 1;184(7):3743-54
• All: 5 reference(s)