Phenotypes Associated with This Genotype

Genotype
MGI:4456428

• Allelic Composition: Apc^tm1Rsmi/Apc⁺; Tg(Fabp1-cre)1Jig/0
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased tumor-free survival time ( J:159883 )

• mice succumb to intestinal tumors later than Apc^tm1.1Ecrm

neoplasm

increased gastrointestinal tumor incidence ( J:159883 )

• mice develop intestinal tumors unlike wild-type mice with later premature death and fewer tumors than Apc^tm1.1Ecrm heterozygotes

• intestinal tumors develop predominantly in the large intestine that are larger than in Apc^tm1.1Ecrm heterozygotes

• large intestine tumors are pedunculated (polypoid) or sessile

increased intestinal adenocarcinoma incidence ( J:159883 )

• intestinal tumors develop predominantly in the large intestine

increased large intestine adenocarcinoma incidence ( J:159883 )

• intestinal tumors develop predominantly in the large intestine

increased small intestine adenocarcinoma incidence ( J:159883 )

• intestinal tumors develop predominantly in the large intestine

increased intestinal adenoma incidence ( J:159883 )

• low and high grade

digestive/alimentary system

increased gastrointestinal tumor incidence ( J:159883 )

• mice develop intestinal tumors unlike wild-type mice with later premature death and fewer tumors than Apc^tm1.1Ecrm heterozygotes

• intestinal tumors develop predominantly in the large intestine that are larger than in Apc^tm1.1Ecrm heterozygotes

• large intestine tumors are pedunculated (polypoid) or sessile

increased intestinal adenocarcinoma incidence ( J:159883 )

• intestinal tumors develop predominantly in the large intestine

increased large intestine adenocarcinoma incidence ( J:159883 )

• intestinal tumors develop predominantly in the large intestine

increased small intestine adenocarcinoma incidence ( J:159883 )

• intestinal tumors develop predominantly in the large intestine

increased intestinal adenoma incidence ( J:159883 )

• low and high grade

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
colorectal cancer		DOID:9256	OMIM:114500	J:159883