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Phenotypes Associated with This Genotype
Genotype
MGI:4456428
Allelic
Composition
Apctm1Rsmi/Apc+
Tg(Fabp1-cre)1Jig/0
Genetic
Background
involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm1Rsmi mutation (1 available); any Apc mutation (61 available)
Tg(Fabp1-cre)1Jig mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• mice develop intestinal tumors unlike wild-type mice with later premature death and fewer tumors than Apctm1.1Ecrm heterozygotes
• intestinal tumors develop predominantly in the large intestine that are larger than in Apctm1.1Ecrm heterozygotes
• large intestine tumors are pedunculated (polypoid) or sessile
• intestinal tumors develop predominantly in the large intestine
• intestinal tumors develop predominantly in the large intestine
• intestinal tumors develop predominantly in the large intestine

mortality/aging
• mice succumb to intestinal tumors later than Apctm1.1Ecrm

neoplasm
• mice develop intestinal tumors unlike wild-type mice with later premature death and fewer tumors than Apctm1.1Ecrm heterozygotes
• intestinal tumors develop predominantly in the large intestine that are larger than in Apctm1.1Ecrm heterozygotes
• large intestine tumors are pedunculated (polypoid) or sessile
• intestinal tumors develop predominantly in the large intestine
• intestinal tumors develop predominantly in the large intestine
• intestinal tumors develop predominantly in the large intestine

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
colorectal cancer DOID:9256 OMIM:114500
J:159883


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory