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Phenotypes Associated with This Genotype
Genotype
MGI:4454429
Allelic
Composition		 a/a
Lystbg/Lystbg
Tyrc/Tyrc
Genetic
Background		 involves: C3H/Rl * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (166 available); any a mutation (468 available)
Lystbg mutation (6 available); any Lyst mutation (227 available)
Tyrc mutation (79 available); any Tyr mutation (382 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
abnormal melanosome morphology ( J:5346 )
• absence of fibrillar melanosomes in the choroid and retina
abnormal choroid melanin granule morphology ( J:5346 )
• number of granules diminishes in adults after birth
abnormal retina melanin granule morphology ( J:5346 )
• number of granules diminishes in adults after birth
abnormal melanogenesis ( J:5346 )
• absence of melanin deposition on premelanosome filaments

vision/eye
abnormal choroid melanin granule morphology ( J:5346 )
• number of granules diminishes in adults after birth
abnormal retina melanin granule morphology ( J:5346 )
• number of granules diminishes in adults after birth

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory