Phenotypes Associated with This Genotype

Genotype
MGI:4454341

• Allelic Composition: Sox11^tm1.1Vlf/Sox11^tm1.1Vlf; Sox4^tm1Vlf/Sox4^tm1Vlf; Tg(Dbh-icre)1Gsc/?
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal Meibomian gland morphology ( J:157923 )

• Meibomian glands lack sympathetic innervation

blepharoptosis ( J:157923 )

• unable to fully open their eyes

nervous system

abnormal stellate ganglion morphology ( J:157923 )

• have only a small rudiment of the stellate ganglion

small superior cervical ganglion ( J:157923 )

• small rudiment

abnormal sympathetic neuron innervation pattern ( J:157923 )

• Meibomian glands, musculus tarsalis and arterioles of the eye lack sympathetic innervation

abnormal innervation pattern to muscle ( J:157923 )

• musculus tarsalis of the eyelid lacks sympathetic innervation

endocrine/exocrine glands

abnormal Meibomian gland morphology ( J:157923 )

• Meibomian glands lack sympathetic innervation

integument

abnormal Meibomian gland morphology ( J:157923 )

• Meibomian glands lack sympathetic innervation