Analysis Tools
mortality/aging
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• fewer than expected mice are present at weaning
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cardiovascular system
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• mice exhibit media hyperplasia of small and medium vessels unlike wild-type mice
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• compared with wild-type mice and Agtr1atm1Unc homozygotes
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• Ang II-treated mice exhibit an almost completely blunted increase in mean arterial blood pressure (MAP) and heart rate with an increased time to normalization of MAP compared with similarly treated wild-type mice
• PE-treated mice exhibit a smaller increase in MAP compared with similarly treated wild-type mice
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homeostasis/metabolism
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• serum levels of Ang II are increased compared to in wild-type mice and Agtr1btm1Cof homozygotes
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• angiotensin II (Ang II)-treated mice exhibit an almost completely blunted increase in mean arterial blood pressure (MAP) and heart rate with an increased time to normalization of MAP compared with similarly treated wild-type mice
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• phenylephrine (PE)-treated mice exhibit a smaller increase in MAP compared with similarly treated wild-type mice
• however, PE-treated mice exhibit a negative chronotropic response as in wild-type mice
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renal/urinary system
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• mice exhibit media hyperplasia of small and medium vessels unlike wild-type mice
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kidney cyst
(
J:137944
)
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• mice exhibit cystic dilated cavities unlike wild-type mice
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• mice exhibit prominent renal mononuclear infiltrations with partially blastic appearance and a high rate of partial mitosis unlike wild-type mice
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• severely dilated Bowman's space
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• multifocal and focally extensive glomeruli atrophy
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• partially dilated tubular lumina unlike in wild-type mice
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growth/size/body
kidney cyst
(
J:137944
)
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• mice exhibit cystic dilated cavities unlike wild-type mice
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immune system
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• mice exhibit prominent renal mononuclear infiltrations with partially blastic appearance and a high rate of partial mitosis unlike wild-type mice
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