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Phenotypes Associated with This Genotype
Genotype
MGI:4453345
Allelic
Composition		 Lhx2tm1.1Lcar/Lhx2tm1Dra
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lhx2tm1.1Lcar mutation (0 available); any Lhx2 mutation (12 available)
Lhx2tm1Dra mutation (0 available); any Lhx2 mutation (12 available)
Tg(CAG-cre/Esr1*)5Amc mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Hair follicles of tamoxifen-treated Lhx2tm1.1Lcar/Lhx2tm1Dra Tg(CAG-cre/Esr1*)5Amc/0 mice arrest during anagen progression and are unable to assemble a normal hair shaft

integument
abnormal hair growth ( J:159209 )
• most mice shaved and treated with Tamoxifen at 3 weeks of age do not regrow hair
abnormal hair cycle anagen phase ( J:159209 )
• unable to develop beyond Sub-stage III and assemble a normal hair shaft

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory