Phenotypes Associated with This Genotype

Genotype
MGI:4437897

• Allelic Composition: Tg(Fabp4-LEP)F8Ffc/0
• Genetic Background: involves: C57BL/6J * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased brown fat lipid droplet number ( J:67311 )

• at 6 to 9 weeks, brown fat adipocytes are devoid of lipid droplets unlike in wild-type mice

• however, by 36 weeks brown fat adipocytes appear normal

abnormal white fat cell morphology ( J:67311 )

• at 6 to 9 weeks, white fat adipocytes contain few lipid droplets unlike in wild-type mice

• however, by 36 weeks white fat adipocytes appear normal

abnormal fat pad morphology ( J:67311 )

• at 6 to 9 weeks, fat pads (such as pericardial, perirenal, mesenteric, and sc fat depots) are absent or too minute to weigh unlike in wild-type mice

• however, at 33 to 36 weeks fat pad weights are normal

abnormal gonadal fat pad morphology ( J:67311 )

• young mice, but not old mice, exhibit a decrease or absence in gonadal white adipose tissue compared with wild-type mice

• at 6 to 9 weeks, brown and white gonadal adipose tissue is reduced 4.2- and 2.6-fold, respectively, compared with wild-type mice

decreased gonadal fat pad weight ( J:67311 )

• gonadal white adipose tissue weighs 13.8- and 8.7-fold less in male and female mice, respectively, than in wild-type mice

abnormal interscapular fat pad morphology ( J:67311 )

• at 6 to 9 weeks, mice exhibit a reduction in brown adipose tissue and absence of white adipose tissue in the interscapular region unlike wild-type mice

• however, by 33 to 36 weeks no interscapular depression is observed

homeostasis/metabolism

impaired adaptive thermogenesis ( J:67311 )

• at 6 to 9 weeks, cold exposed male and female mice exhibit a drop in body temperature within 6 to 9 hours and 2 to 22 hours, respectively, unlike similarly treated wild-type mice

• however, mice exhibit normal body temperature regulation at 33 to 36 weeks or in young mice fed a high fat diet

decreased circulating glucose level ( J:67311 )

• at 6 to 9 weeks

decreased circulating insulin level ( J:67311 )

• at 6 to 9 weeks, plasma insulin levels are 4- and 3-fold less in males and female mice, respectively, compared with wild-type mice

• at 33 to 36 weeks, plasma insulin levels are 2.7-fold lower in male, but not female, mice compared to in wild-type mice

increased circulating leptin level ( J:67311 )

• at 6 to 9 weeks and 33 to 36 weeks, male mice exhibit a 4- and 4.9-fold, respectively, increased over endogenous levels

• at 6 to 9 weeks and 33 to 36 weeks, female mice exhibit a 2.5- and 4.2-fold, respectively, increased over endogenous levels

decreased circulating cholesterol level ( J:67311 )

• at 6 to 9 weeks

decreased circulating triglyceride level ( J:67311 )

• at 6 to 9 weeks, plasma triglyceride levels are 2- and 3-fold lower in males and female mice, respectively, compared with wild-type mice

growth/size/body

decreased body weight ( J:67311 )

• body weight distribution shifts leftward of the bell-shaped curves of transgenic versus nontransgenic mice

• young mice exhibit a decrease in carcass weight compared with wild-type mice that accounts for differences in body weight

liver/biliary system

small liver ( J:67311 )

• 1.4-fold in young mice

behavior/neurological

abnormal eating behavior ( J:67311 )

• at a young age but not at 33 to 36 weeks