Tg(Fabp4-LEP)F8Ffc
Transgene Detail
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Symbol: |
Tg(Fabp4-LEP)F8Ffc |
Name: |
transgene insertion F8, Farid F Chehab |
MGI ID: |
MGI:4437889 |
Synonyms: |
LepTg |
Transgene: |
Tg(Fabp4-LEP)F8Ffc Location: unknown
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Alliance: |
Tg(Fabp4-LEP)F8Ffc page
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Strain of Origin: |
C57BL/6J x DBA/2J
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Fabp4-LEP)F8Ffc expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
LEP (3952) |
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Mutation details: The Fabp4-LEP transgene was designed with the mouse aP2 promoter driving the expression of the human leptin (LEP) gene. Fabp4-LEP consists of, from 5' to 3', an aP2 promoter/enhancer, rabbit beta-globin, human leptin cDNA, and human growth hormone (hGH) polyadenylation (polyA) signal. One line, F8, was generated. Expression of the transgene was detected in brown adipose tissue, all white adipose tissue depots and in macrophages.
(J:67311)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:67311 Qiu J, et al., Transgenic mice overexpressing leptin accumulate adipose mass at an older, but not younger, age. Endocrinology. 2001 Jan;142(1):348-58 |
All: |
4 reference(s) |
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