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Phenotypes Associated with This Genotype
Genotype
MGI:4430558
Allelic
Composition		 Foxo1tm1.1Rdp/Foxo1+
Igh-Jtm1Cgn/Ightm4Cgn
Tg(Cr2-cre)3Cgn/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1tm1.1Rdp mutation (0 available); any Foxo1 mutation (34 available)
Igh-Jtm1Cgn mutation (3 available); any Igh-J mutation (12 available)
Ightm4Cgn mutation (0 available); any Igh mutation (47 available)
Tg(Cr2-cre)3Cgn mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased B cell number ( J:157297 )
• mice exhibit a limited rescue of IgM negative B cells compared to in Igh-Jtm1Cgn/Ightm4Cgn Tg(Cr2-cre)3Cgn mice

hematopoietic system
increased B cell number ( J:157297 )
• mice exhibit a limited rescue of IgM negative B cells compared to in Igh-Jtm1Cgn/Ightm4Cgn Tg(Cr2-cre)3Cgn mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory