Phenotypes Associated with This Genotype

Genotype
MGI:4429631

• Allelic Composition: Hr^hr/Hr^hr; Msh2^tm1Htr/Msh2^tm1Htr; Xpa^tm1Tnka/Xpa^tm1Tnka
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased mortality induced by ionizing radiation ( J:79734 )

• 32% of mice die 15 weeks after UVB-irradiation compared with 3% of similarly treated Xpa^tm1Tnka homozygotes

premature death ( J:79734 )

• 18% of mice die of lymphomas by 20 weeks of age

neoplasm

increased skin tumor incidence ( J:79734 )

• in 81% of mice by 52 weeks

increased skin papilloma incidence ( J:79734 )

• 9% of spontaneous skin tumors are papillomas

increased skin squamous cell carcinoma incidence ( J:79734 )

• 91% of skin tumors are squamous cell carcinomas

• all skin tumors in UVB-treated mice are diagnosed as squamous cell carcinomas

increased lymphoma incidence ( J:79734 )

• 18% of mice die of lymphomas by 20 weeks of age

increased incidence of tumors by UV-induction ( J:79734 )

• UVB-treated mice develop skin tumors a week earlier than similarly treated Xpa^tm1Tnka homozygotes

• all UVB-treated mice develop skin tumors, all of which are squamous cell carcinomas, at 10 weeks compared with 20 weeks for similarly treated Xpa^tm1Tnka homozygotes

integument

increased skin tumor incidence ( J:79734 )

• in 81% of mice by 52 weeks

increased skin papilloma incidence ( J:79734 )

• 9% of spontaneous skin tumors are papillomas

increased skin squamous cell carcinoma incidence ( J:79734 )

• 91% of skin tumors are squamous cell carcinomas

• all skin tumors in UVB-treated mice are diagnosed as squamous cell carcinomas

homeostasis/metabolism

increased mortality induced by ionizing radiation ( J:79734 )

• 32% of mice die 15 weeks after UVB-irradiation compared with 3% of similarly treated Xpa^tm1Tnka homozygotes