Phenotypes Associated with This Genotype

Genotype
MGI:4429609

• Allelic Composition: Msh2^tm1Htr/Msh2^tm1Htr; Tap1^tm1Hpl/Tap1^tm1Hpl
• Genetic Background: involves: 129P2/OlaHsd * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased tumor incidence ( J:45433 )

• mice that survive beyond 30 weeks exhibit a multitude of tumors types (erythroid, intestine, skin, uterus, mammary gland, lung, intestine, and hereditary nonpolyposis colorectal cancer)

increased gastrointestinal tumor incidence ( J:45433 )

• 80% of mice that survive beyond 30 weeks develop Hereditary Nonpolyposis Colon Cancer (HNPCC) tumors

increased mammary gland tumor incidence ( J:45433 )

• in mice that survive beyond 30 weeks

increased skin tumor incidence ( J:45433 )

• in mice that survive beyond 30 weeks

increased uterus tumor incidence ( J:45433 )

♀ • in mice that survive beyond 30 weeks

increased lung tumor incidence ( J:45433 )

• in mice that survive beyond 30 weeks

integument

increased mammary gland tumor incidence ( J:45433 )

• in mice that survive beyond 30 weeks

increased skin tumor incidence ( J:45433 )

• in mice that survive beyond 30 weeks

reproductive system

increased uterus tumor incidence ( J:45433 )

♀ • in mice that survive beyond 30 weeks

digestive/alimentary system

increased gastrointestinal tumor incidence ( J:45433 )

• 80% of mice that survive beyond 30 weeks develop Hereditary Nonpolyposis Colon Cancer (HNPCC) tumors

respiratory system

increased lung tumor incidence ( J:45433 )

• in mice that survive beyond 30 weeks

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:45433 )

• in mice that survive beyond 30 weeks

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Lynch syndrome		DOID:3883	OMIM:PS120435	J:45433