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Phenotypes Associated with This Genotype
Genotype
MGI:4429609
Allelic
Composition
Msh2tm1Htr/Msh2tm1Htr
Tap1tm1Hpl/Tap1tm1Hpl
Genetic
Background
involves: 129P2/OlaHsd * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh2tm1Htr mutation (0 available); any Msh2 mutation (44 available)
Tap1tm1Hpl mutation (1 available); any Tap1 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
tumorigenesis
• mice that survive beyond 30 weeks exhibit a multitude of tumors types (erythroid, intestine, skin, uterus, mammary gland, lung, intestine, and hereditary nonpolyposis colorectal cancer) (J:45433)
• mice that survive beyond 30 weeks exhibit a multitude of tumors types (erythroid, intestine, skin, uterus, mammary gland, lung, intestine, and hereditary nonpolyposis colorectal cancer) (J:45433)
• in mice that survive beyond 30 weeks (J:45433)
• in mice that survive beyond 30 weeks (J:45433)
• 80% of mice that survive beyond 30 weeks develop Hereditary Nonpolyposis Colon Cancer (HNPCC) tumors (J:45433)
• 80% of mice that survive beyond 30 weeks develop Hereditary Nonpolyposis Colon Cancer (HNPCC) tumors (J:45433)
• in mice that survive beyond 30 weeks (J:45433)
• in mice that survive beyond 30 weeks (J:45433)
• in mice that survive beyond 30 weeks (J:45433)
• in mice that survive beyond 30 weeks (J:45433)
• in mice that survive beyond 30 weeks (J:45433)
• in mice that survive beyond 30 weeks (J:45433)

integument
• in mice that survive beyond 30 weeks (J:45433)
• in mice that survive beyond 30 weeks (J:45433)

Mouse Models of Human Disease
OMIM ID Ref(s)
Lynch Syndrome I 120435 J:45433


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory