Analysis Tools
mortality/aging
|
• when exposed to 7 Gy ionizing radiation, all mice die within 9 days, where 80% of wild-type mice survive
|
|
• birth rate is lower than expected, no time of lethality provided
|
reproductive system
 |
• at P56, absence of spermatids in seminiferous tubules
|
|
|
• fewer spermatocytes are produced in seminiferous tubules
|
|
|
• increase in TUNEL+ cells in tubules
|
|
|
• significantly smaller and thinner than those of wild-type at P28
|
small testis
(
J:156371
)
|
|
• testes are consistently smaller especially after 3-weeks of age
|
|
|
• interstitial initiation of synapsis with asynapsis on either side of the contact
• incomplete, dashed-line shape bivalents in many homologs during zygotene or zygotene/pachytene
• double-strand breaks cannot be appropriately repaired
|
|
|
• meiotic dysregulation at P14, P21, and P56, spermatocytes arrest prior to the pachytene stage
• increase in zygotene spermatocytes and a complete absence of postmeitotic cells
|
endocrine/exocrine glands
|
|
• significantly smaller and thinner than those of wild-type at P28
|
small testis
(
J:156371
)
|
|
• testes are consistently smaller especially after 3-weeks of age
|
cellular
|
|
• at P56, absence of spermatids in seminiferous tubules
|
|
|
• fewer spermatocytes are produced in seminiferous tubules
|
|
• MEFs are more sensitive to ionizing radiation, as measure by number of cells surviving after 6 days
|
|
|
• increase in TUNEL+ cells in tubules
|
|
• increased chromosomal breakage in MEFs 3 and 20 hrs after ionizing radiation treatment
|
growth/size/body
|
• at P56 weight is only 80% of wild-type
|
immune system
|
• increase in number of chromosomal aberrations in T cells
|
hematopoietic system
|
• increase in number of chromosomal aberrations in T cells
|
homeostasis/metabolism
|
• when exposed to 7 Gy ionizing radiation, all mice die within 9 days, where 80% of wild-type mice survive
|
