Phenotypes Associated with This Genotype

Genotype
MGI:4420251

• Allelic Composition: Lfng^tm1Rjo/Lfng^tm1Rjo
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Regional and dose-dependent rescue of the Lfng phenotype by transgenic expression in the stripe domain

mortality/aging

decreased survivor rate ( J:155378 )

• relative viability compared to wild-type controls is 9%

preweaning lethality, incomplete penetrance ( J:155378 )

• most die before weaning

skeleton

decreased caudal vertebrae number ( J:155378 )

• have either 1 or 0 tail vertebrae

absent caudal vertebrae ( J:155378 )

• have either 1 or 0 tail vertebrae

abnormal sclerotome morphology ( J:155378 )

• at E10.5 - E11.5, sclerotomes cranial to the hindlimb buds are fused and borders never become as visible as in wild-type controls

• at E11.5 the PAX1 domain in the tail is thicker indicating limited formation of the scleretome

embryo

abnormal rostral-caudal axis patterning ( J:123846 )

• embryos are rostralized,compared to wild-type

caudal body truncation ( J:155378 )

• axial extension ceases around E10.5 resulting in a truncated tail

abnormal somite development ( J:155378 )

• somites become increasingly irregular towards the end of the tail

• however, segmentation in the sacrum and adjacent tail area is regular

limbs/digits/tail

decreased caudal vertebrae number ( J:155378 )

• have either 1 or 0 tail vertebrae

absent caudal vertebrae ( J:155378 )

• have either 1 or 0 tail vertebrae

short tail ( J:155378 )

• unsegmented tail stump