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Phenotypes Associated with This Genotype
Genotype
MGI:4413583
Allelic
Composition
Wt1tm1.1Lahe/Wt1+
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * FVB/NCrl * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wt1tm1.1Lahe mutation (0 available); any Wt1 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• average lifespan is 4.6 months

renal/urinary system
• Background Sensitivity: at 2 to 8 months, 6 of 9 male mice from the first generation (N1) on a background containing FVB exhibit heavy proteinuria unlike mice backcrossed to a C57BL/6 background for 4 generations
• all mice from N2, N3, and N4 generations on the FVB containing background develop proteinuria by 2 weeks and 2 months unlike wild-type mice
• parietal cells stain for anti-IgG and anti-IgM antibodies unlike in wild-type mice
• in male mice, GBM thickening is sometimes associated with podocyte hypertrophy and vacuolation unlike in wild-type mice
• in male mice, GBM thickening is sometimes associated with podocyte hypertrophy
• by the onset of proteinuria, male mice develop a GBM thickening that is sometimes associated with podocyte hypertrophy and vacuolation unlike in wild-type mice
• glomerular lesions are frequently more severe at the periphery of the cortex with enlarged deeper glomeruli that are less affected
• mesangial cells stain for anti-IgG and anti-IgM antibodies unlike in wild-type mice
• mice develop mesangial slerosis unlike in wild-type mice
• mice develop mesangiolysis unlike in wild-type mice
• all mice develop glomerulosclerosis with tubular damages with female mice developing renal pathologies later than male mice

homeostasis/metabolism
• Background Sensitivity: at 2 to 8 months, 6 of 9 male mice from the first generation (N1) on a background containing FVB exhibit heavy proteinuria unlike mice backcrossed to a C57BL/6 background for 4 generations
• all mice from N2, N3, and N4 generations on the FVB containing background develop proteinuria by 2 weeks and 2 months unlike wild-type mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Denys-Drash syndrome DOID:3764 OMIM:194080
J:154995


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory