Phenotypes Associated with This Genotype

Genotype
MGI:4411989

• Allelic Composition: Stk3^tm1Jav/Stk3^tm1Jav; Stk4^{Gt(AJ0315)Wtsi}/Stk4^{Gt(AJ0315)Wtsi}
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

increased hepatocyte proliferation ( J:153945 )

• 4-fold increase in hepatocyte proliferation by Ki-67 staining at day 8 after Adeno-Cre administration

liver hyperplasia ( J:153945 )

• injecting of Adenovirus expressing Cre recombinase (Adeno-Cre) into the tail vein at 6 weeks old to induce liver-specific deletion

• a prominent increase in liver size as early as 3 days after Adeno-Cre administration

• 2-fold larger at 8 days and 4-fold larger by 3 months

increased hepatocellular carcinoma incidence ( J:153945 )

• with a mean latency of 10 weeks after Adeno-Cre injection

• the presence of multifocal hepatocellular carcinomas (HCCs) against the backdrop of hyperplastic, but untransformed, hepatocytes

neoplasm

increased hepatocellular carcinoma incidence ( J:153945 )

• with a mean latency of 10 weeks after Adeno-Cre injection

• the presence of multifocal hepatocellular carcinomas (HCCs) against the backdrop of hyperplastic, but untransformed, hepatocytes

cellular

increased hepatocyte proliferation ( J:153945 )

• 4-fold increase in hepatocyte proliferation by Ki-67 staining at day 8 after Adeno-Cre administration

growth/size/body

liver hyperplasia ( J:153945 )

• injecting of Adenovirus expressing Cre recombinase (Adeno-Cre) into the tail vein at 6 weeks old to induce liver-specific deletion

• a prominent increase in liver size as early as 3 days after Adeno-Cre administration

• 2-fold larger at 8 days and 4-fold larger by 3 months