Phenotypes Associated with This Genotype

Genotype
MGI:4410326

• Allelic Composition: Rpe65^450L/Rpe65^450L
• Genetic Background: BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

thin retina outer nuclear layer ( J:154536 )

• reduced thickness of the retinal outer nuclear layer (ONL) after light (5000-lux light for 15 minutes) exposure

• antioxidants treatment (3 hours before light exposure) preserves the thickness of the ONLs

retina outer nuclear layer degeneration ( J:154536 )

• light (5000-lux light for 15 minutes)-induced retinal degeneration

• antioxidants treatment (3 hours before light exposure) ameliorated retinal degeneration