Analysis Tools
reproductive system
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• 17beta-estradiol-induced increase in uterus weight is less than in similarly treated wild-type mice
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• during a 30 min interaction with a receptive female males failed to show any ejaculations
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behavior/neurological
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• in a resident intruder assay aggressive behaviors toward the intruder male are greatly reduced and mice rarely show offensive attacks
• loss of offensive attacks is also seen when males are tested in a neutral cage
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• about 50% of males display defensive type aggression towards receptive females
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• during a 30 min interaction with a receptive female males failed to show any ultrasonic vocalizations, mounts, or intromissions; similar results are seen when the interaction is extended to 90 min
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skeleton
short femur
(
J:62222
)
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• in post-pubertal mice
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• bone mineral content normalized to body weight is decreased in the total body, femur and spine
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• total areal bone mineral density is slightly decreased in adults
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• femur bone mineral density is decreased in adults
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• decrease in mid-diaphyseal bone mineral content in the femur and tibia mainly as a result of a decrease in cross-sectional area associated with a decrease in periosteal and endosteal circumference
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homeostasis/metabolism
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• in males at 4 months of age but not at 1 or 2 months of age
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• decrease in the concentration of osteocalcin, a marker of bone formation, in the serum at 110 days of age
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• in adult males
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• in adult males
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• in males at 4 months of age the insulin x free fatty acid product is increased suggesting the mice are insulin resistant
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• 17beta-estradiol-induced increase in uterus weight is less than in similarly treated wild-type mice
(J:115411)
• treatment with 17beta-estradiol fails to inhibit vascular injury-induced increases in medial area unlike in similarly treated wild-type mice
(J:115411)
• however, vascular smooth muscle cell proliferation following injury and 17beta-estradiol treatment is normal
(J:115411)
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• 17beta-estradiol-treated castrated mice fail to exhibit a decrease in bone marrow cellularity, a reduced decrease in the frequency of B cells, immunoglobulin switching, or an increase in production of immunoglobulins (IgA, IgG, and IgM) unlike similarly treated wild-type mice
(J:82423)
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growth/size/body
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• late pubertal and young adult body weight is decreased compared to controls
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limbs/digits/tail
short femur
(
J:62222
)
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• in post-pubertal mice
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immune system
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• 17beta-estradiol-treated castrated mice fail to exhibit immunoglobulin switching unlike similarly treated wild-type mice
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• mice have increased double positive CD4+CD8+ thymocytes compared to in wild-type mice
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• 17beta-estradiol-treated castrated mice fail to exhibit a reduced decrease in the frequency of B cells (including pre-B cells, pro-B cells, and newly formed B cells) compared with similarly treated wild-type mice
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• mice have fewer single positive CD4+ and CD8+ thymocytes compared to in wild-type mice
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• mice have fewer single positive CD4+ and CD8+ thymocytes compared to in wild-type mice
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• 17beta-estradiol-treated castrated mice fail to exhibit an increase in production of immunoglobulins (IgA, IgG, and IgM) compared with similarly treated wild-type mice
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adipose tissue
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• in males at 4 months of age but not at 1 or 2 months of age
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• in males at 4 months of age
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• in males at 4 months of age
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hematopoietic system
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• 17beta-estradiol-treated castrated mice fail to exhibit immunoglobulin switching unlike similarly treated wild-type mice
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• mice have increased double positive CD4+CD8+ thymocytes compared to in wild-type mice
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• 17beta-estradiol-treated castrated mice fail to exhibit a decrease in bone marrow cellularity unlike similarly treated wild-type mice
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• 17beta-estradiol-treated castrated mice fail to exhibit a reduced decrease in the frequency of B cells (including pre-B cells, pro-B cells, and newly formed B cells) compared with similarly treated wild-type mice
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• mice have fewer single positive CD4+ and CD8+ thymocytes compared to in wild-type mice
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• mice have fewer single positive CD4+ and CD8+ thymocytes compared to in wild-type mice
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• 17beta-estradiol-treated castrated mice fail to exhibit an increase in production of immunoglobulins (IgA, IgG, and IgM) compared with similarly treated wild-type mice
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endocrine/exocrine glands
