Phenotypes Associated with This Genotype

Genotype
MGI:4397687

• Allelic Composition: Pdcd1^tm1.1Shr/Pdcd1^tm1.1Shr; Tg(TcraTcrb)1100Mjb/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased T cell proliferation ( J:153040 )

• following adoptive transfer, naive CD8+ T cells exhibit no proliferation in RIP-ova^low recipients unlike similarly treated wild-type cells

increased T cell proliferation ( J:153040 )

• following adoptive transfer, T cells exhibit increased cell intrinsic proliferation in RIP-ova^high recipients unlike similarly treated wild-type cells

pancreas inflammation ( J:153040 )

• following adoptive transfer, CD8+ T cells induce peri-ductal infiltrates and vasculitis within the pancreas in RIP-ova^high recipients unlike similarly treated wild-type cells

insulitis ( J:153040 )

• following adoptive transfer, CD8+ T cells induce severe insulitis in RIP-ova^high recipients unlike similarly treated wild-type cells

abnormal immune tolerance ( J:153040 )

• following adoptive transfer, CD8+ T cells fail to undergo cross-tolerization when transplanted into RIP-ova^high recipients unlike similarly treated wild-type cells

increased susceptibility to autoimmune diabetes ( J:153040 )

• following adoptive transfer, CD8+ T cells induce diabetes in RIP-ova^high or RIP-ova^low recipients unlike similarly treated wild-type cells

cardiovascular system

vascular inflammation ( J:153040 )

• following adoptive transfer, CD8+ T cells induce vasculitis within the pancreas in RIP-ova^high recipients unlike similarly treated wild-type cells

endocrine/exocrine glands

pancreas inflammation ( J:153040 )

• following adoptive transfer, CD8+ T cells induce peri-ductal infiltrates and vasculitis within the pancreas in RIP-ova^high recipients unlike similarly treated wild-type cells

insulitis ( J:153040 )

• following adoptive transfer, CD8+ T cells induce severe insulitis in RIP-ova^high recipients unlike similarly treated wild-type cells

hematopoietic system

decreased T cell proliferation ( J:153040 )

• following adoptive transfer, naive CD8+ T cells exhibit no proliferation in RIP-ova^low recipients unlike similarly treated wild-type cells

increased T cell proliferation ( J:153040 )

• following adoptive transfer, T cells exhibit increased cell intrinsic proliferation in RIP-ova^high recipients unlike similarly treated wild-type cells

cellular

decreased T cell proliferation ( J:153040 )

• following adoptive transfer, naive CD8+ T cells exhibit no proliferation in RIP-ova^low recipients unlike similarly treated wild-type cells

increased T cell proliferation ( J:153040 )

• following adoptive transfer, T cells exhibit increased cell intrinsic proliferation in RIP-ova^high recipients unlike similarly treated wild-type cells