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Phenotypes Associated with This Genotype
Genotype
MGI:4397588
Allelic
Composition
Gtsf1tm1Miya/Gtsf1tm1Miya
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gtsf1tm1Miya mutation (1 available); any Gtsf1 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• female mice exhibit normal ovary morphology and fertility
• at 5 months, male mice exhibit a depletion of meiotic cells, post-meiotic cells, and mature sperm cells compared with wild-type mice
• beginning at P14 and more prevalent at P18
• at leptotene with increased staining for double strand breaks
• beginning at P14 and more prevalent at P18
• despite normal copulation

endocrine/exocrine glands

cellular
• at 5 months, male mice exhibit a depletion of meiotic cells, post-meiotic cells, and mature sperm cells compared with wild-type mice
• beginning at P14 and more prevalent at P18
• at leptotene with increased staining for double strand breaks
• beginning at P14 and more prevalent at P18


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/06/2026
MGI 6.24
The Jackson Laboratory