Phenotypes Associated with This Genotype

Genotype
MGI:4368025

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Trp53^tm1Brn/Trp53^tm1Brn; Tg(Scgb1a1-rtTA)1Jaw/0
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

abnormal tumor morphology ( J:154041 )

• infiltrating inflammatory cells recruited to tumors in which NF-kB has been inhibited

• tumorigenesis is initiated by infection with lentiviruses expressing Cre and Nfkbia lentiviruses

decreased tumor growth/size ( J:154041 )

• doxycycline (Dox)-mediated induction of Nfkbia expression specifically in the tumor cells starting at 16 weeks after tumor initiation results in a significantly diminished tumour growth rate

• tumorigenesis is initiated by infection with lentiviruses expressing Cre and Nfkbia lentiviruses

decreased incidence of induced tumors ( J:154041 )

• doxycycline (Dox)-mediated induction of Nfkbia expression specifically in the tumor cells leads to a significant impairment of tumour development

• tumorigenesis is initiated by infection with lentiviruses expressing Cre and Nfkbia lentiviruses