Phenotypes Associated with This Genotype

Genotype
MGI:4367200

• Allelic Composition: Gt(ROSA)26Sor^{tm1(sb11)Njen}/Gt(ROSA)26Sor⁺; TgTn(sb-T2/Onc3)12740Njen/0
• Genetic Background: involves: C3H * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:153656 )

• compared with Gt(ROSA)26Sor^{tm1(sb11)Njen} mice

neoplasm

increased pheochromocytoma incidence ( J:153656 )

• in one mouse

increased liver tumor incidence ( J:153656 )

• liver tumors metastasize to the lungs

increased hepatocellular carcinoma incidence ( J:153656 )

• 23 tumors in 62 with mice greater prevalent in male than female mice

increased liver adenoma incidence ( J:153656 )

• 58 tumors in 62 mice with greater prevalent in male than female mice

increased adenoma incidence ( J:153656 )

• 23 adenomas with multiple locations develop in 62 mice

increased hemangioma incidence ( J:153656 )

• 7 hemangiomas with multiple locations develop in 62 mice

increased lymphoma incidence ( J:153656 )

• in 11% of mice (7 tumors in 62 mice)

increased T cell derived lymphoma incidence ( J:153656 )

• 3 tumors in 62 mice

increased B cell derived lymphoma incidence ( J:153656 )

• 5 tumors in 62 mice

increased blastoma incidence ( J:153656 )

• in one mouse

increased carcinoma incidence ( J:153656 )

• mice develop carcinomas in the colon (1 tumors in 62 mice), lung (3 in 62), mammary gland (5 in 62), salivary gland (1 in 62), preputial gland (12 in 62), parathyroid (1 in 62), and nasal cavity (1 in 62)

increased basal cell carcinoma incidence ( J:153656 )

• in one mouse

increased lung carcinoma incidence ( J:153656 )

• 3 tumors in 62 mice

increased squamous cell carcinoma incidence ( J:153656 )

• one mouse developed a squamous cell carcinoma in the clitoral gland

• one mouse developed a squamous cell carcinoma in the salivary gland

increased skin squamous cell carcinoma incidence ( J:153656 )

• 27 tumors in 62 mice

increased melanoma incidence ( J:153656 )

• one mouse developed a melanoma

increased sarcoma incidence ( J:153656 )

• 2 sarcomas with multiple locations develop in 62 mice

increased hemangiosarcoma incidence ( J:153656 )

• 4 tumors in 62 mice

integument

increased basal cell carcinoma incidence ( J:153656 )

• in one mouse

increased skin squamous cell carcinoma incidence ( J:153656 )

• 27 tumors in 62 mice

endocrine/exocrine glands

increased pheochromocytoma incidence ( J:153656 )

• in one mouse

increased T cell derived lymphoma incidence ( J:153656 )

• 3 tumors in 62 mice

liver/biliary system

increased liver tumor incidence ( J:153656 )

• liver tumors metastasize to the lungs

increased hepatocellular carcinoma incidence ( J:153656 )

• 23 tumors in 62 with mice greater prevalent in male than female mice

increased liver adenoma incidence ( J:153656 )

• 58 tumors in 62 mice with greater prevalent in male than female mice

respiratory system

increased lung carcinoma incidence ( J:153656 )

• 3 tumors in 62 mice

immune system

increased T cell derived lymphoma incidence ( J:153656 )

• 3 tumors in 62 mice

hematopoietic system

increased T cell derived lymphoma incidence ( J:153656 )

• 3 tumors in 62 mice