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Phenotypes Associated with This Genotype
Genotype
MGI:4362058
Allelic
Composition		 Vav1tm1Tyb/Vav1tm1Tyb
Vav2tm1Kdf/Vav2tm1Kdf
Vav3tm1Swat/Vav3tm1Swat
Genetic
Background		 involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vav1tm1Tyb mutation (2 available); any Vav1 mutation (58 available)
Vav2tm1Kdf mutation (1 available); any Vav2 mutation (45 available)
Vav3tm1Swat mutation (0 available); any Vav3 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal neutrophil physiology ( J:145345 )
• LPS- or peptidoglycan-stimulated reactive oxygen intermediate (ROI) production by neutrophils is blocked compared to in similarly treated wild-type cells
• however, ROI production in response to PMA stimulation is normal
abnormal NK cell physiology ( J:187430 )
• NK cells exhibit reduced conjugation with RMA-S cells compared with wild-type cells
abnormal macrophage physiology ( J:145345 )
• LPS-stimulated bone marrow-derived macrophages fail to generate oxidative burst unlike similarly treated wild-type cells
• however, mice exhibit normal bone marrow-derived macrophages response to PMA stimulation and reactive nitrogen and prostaglandin production in response to LPS
• despite normal phagocytosis, bone marrow-derived macrophages stimulated with unopsonized heat-killed E. coli fail to generate reactive oxygen intermediate unlike similarly treated wild-type cells
decreased interleukin-10 secretion ( J:145345 )
• from LPS-stimulated bone marrow-derived macrophages
decreased tumor necrosis factor secretion ( J:145345 )
• from LPS-stimulated bone marrow-derived macrophages

hematopoietic system
abnormal neutrophil physiology ( J:145345 )
• LPS- or peptidoglycan-stimulated reactive oxygen intermediate (ROI) production by neutrophils is blocked compared to in similarly treated wild-type cells
• however, ROI production in response to PMA stimulation is normal
abnormal NK cell physiology ( J:187430 )
• NK cells exhibit reduced conjugation with RMA-S cells compared with wild-type cells
abnormal macrophage physiology ( J:145345 )
• LPS-stimulated bone marrow-derived macrophages fail to generate oxidative burst unlike similarly treated wild-type cells
• however, mice exhibit normal bone marrow-derived macrophages response to PMA stimulation and reactive nitrogen and prostaglandin production in response to LPS
• despite normal phagocytosis, bone marrow-derived macrophages stimulated with unopsonized heat-killed E. coli fail to generate reactive oxygen intermediate unlike similarly treated wild-type cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory