Phenotypes Associated with This Genotype

Genotype
MGI:4361838

• Allelic Composition: Fas^lpr/Fas^lpr; Spp1^tm1Rit/Spp1^tm1Rit
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * MRL/Mp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

enlarged spleen ( J:73396 )

• at day 175 compared with wild-type mice with further increase at day 275 compared with Fas^lpr homozygotes

increased IgA level ( J:73396 )

• at day 275 compared with wild-type mice

• however, at day 175 IgA levels are normal unlike in Fas^lpr homozygotes

increased IgG1 level ( J:73396 )

• at day 275 compared with wild-type mice

• however, at day 175 IgG1 levels are normal unlike in Fas^lpr homozygotes

increased IgG2a level ( J:73396 )

• at day 275 compared with wild-type mice

• however, at day 175 IgG2a levels are normal unlike in Fas^lpr homozygotes

increased IgG2b level ( J:73396 )

• at day 275 compared with wild-type mice

• however, at day 175 IgG2b levels are normal unlike in Fas^lpr homozygotes

increased IgG3 level ( J:73396 )

• at day 275 compared with wild-type mice

• however, at day 175 IgG3 levels are normal unlike in Fas^lpr homozygotes

increased IgM level ( J:73396 )

• at day 275 compared with wild-type mice

• however, at day 175 IgM levels are normal unlike in Fas^lpr homozygotes

lymph node hyperplasia ( J:73396 )

• at day 175 compared with wild-type mice with further increase at day 275 compared with Fas^lpr homozygotes

increased anti-double stranded DNA antibody level ( J:73396 )

• at day 275

increased anti-single stranded DNA antibody level ( J:73396 )

• at day 275

kidney inflammation ( J:73396 )

• mice exhibit moderate nephritis that worsens from day 175 to 215 unlike either single homozygote

renal/urinary system

kidney inflammation ( J:73396 )

• mice exhibit moderate nephritis that worsens from day 175 to 215 unlike either single homozygote

hematopoietic system

enlarged spleen ( J:73396 )

• at day 175 compared with wild-type mice with further increase at day 275 compared with Fas^lpr homozygotes

increased IgA level ( J:73396 )

• at day 275 compared with wild-type mice

• however, at day 175 IgA levels are normal unlike in Fas^lpr homozygotes

increased IgG1 level ( J:73396 )

• at day 275 compared with wild-type mice

• however, at day 175 IgG1 levels are normal unlike in Fas^lpr homozygotes

increased IgG2a level ( J:73396 )

• at day 275 compared with wild-type mice

• however, at day 175 IgG2a levels are normal unlike in Fas^lpr homozygotes

increased IgG2b level ( J:73396 )

• at day 275 compared with wild-type mice

• however, at day 175 IgG2b levels are normal unlike in Fas^lpr homozygotes

increased IgG3 level ( J:73396 )

• at day 275 compared with wild-type mice

• however, at day 175 IgG3 levels are normal unlike in Fas^lpr homozygotes

increased IgM level ( J:73396 )

• at day 275 compared with wild-type mice

• however, at day 175 IgM levels are normal unlike in Fas^lpr homozygotes

growth/size/body

enlarged spleen ( J:73396 )

• at day 175 compared with wild-type mice with further increase at day 275 compared with Fas^lpr homozygotes