Phenotypes Associated with This Genotype

Genotype
MGI:4361557

• Allelic Composition: Lpin1²⁰⁸⁸⁴/Lpin1²⁰⁸⁸⁴
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased grip strength ( J:153042 )

• mild weakness is seen in the hindpaws from about 8 to 12 weeks of age

• hindlimb grip strength is significantly increased compared to controls at 48 weeks of age

• however, forelimb grip strength is normal

abnormal gait ( J:153042 )

• subtle floppy gait that develops between 6 and 9 weeks of age

nervous system

abnormal myelin sheath morphology ( J:153042 )

• at 12 weeks of age some axons in the sciatic nerve have thin myelin sheaths

• at 12 weeks of age compact myelin structures are seen beside axons within Schwann cells

• at 52 weeks of age some axons with thin myelin sheaths are still present but the overall state of myelination has improved

abnormal sciatic nerve morphology ( J:153042 )

• at 8 weeks of age demyelinated axons are present and darkly stained debris is seen in the sciatic nerve

• appear less well organized compared to controls

demyelination ( J:153042 )

• at 8 and 12 weeks of age demyelinated axons are present in the sciatic nerve

• at 52 weeks of age some demyelinated axons are still present but the overall state of myelination has improved

• demyelination peaks at 8 weeks of age

abnormal action potential ( J:153042 )

• compound muscle action potentials are reduced at 12 weeks of age in the sciatic nerve and the sural nerve

decreased nerve conduction velocity ( J:153042 )

• by 8 weeks of age conduction velocity is reduced in the sciatic nerve and the sural nerve

• decrease is less than in Lpin1²⁰⁸⁸⁴ Nrcam²⁰⁸⁸⁴ double homozygotes

skeleton

decreased joint mobility ( J:153042 )

• at 48 weeks of age joint stiffness is seen in the joints of the paws which is associated with an increase in hindpaw grip strength