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Phenotypes Associated with This Genotype
Genotype
MGI:4361342
Allelic
Composition
a/a
Hps6ru/Hps6ru
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (166 available); any a mutation (468 available)
Hps6ru mutation (3 available); any Hps6 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• the black pigment in the coat is reduced on this background and is described as sepia, reddish-brown or slate-black
• yellow coat pigment in hair behind the ears, surrounding the mammae, and in the perineum is slightly diluted
• electron microscopy shows reduced numbers of melanosomes in the retinal pigment epithelium, those that are found have abnormal morphology including multilamellar or granular inclusions, and choroidal melanosomes are also often misshapen and less dense than normal and tend to be clumped within multimelanosomal bodies (J:81444)
• at birth the iris pigment ring is lacking and adults have ruby colored eyes (J:13122)
• the number of melanocytes in the retina, ear skin, Harderian gland, are greatly reduced
• eyes are unpigmented at birth but later, when opened, are a dark ruby color

vision/eye
• electron microscopy shows reduced numbers of melanosomes in the retinal pigment epithelium, those that are found have abnormal morphology including multilamellar or granular inclusions, and choroidal melanosomes are also often misshapen and less dense than normal and tend to be clumped within multimelanosomal bodies (J:81444)
• at birth the iris pigment ring is lacking and adults have ruby colored eyes (J:13122)
• eyes are unpigmented at birth but later, when opened, are a dark ruby color

integument
• the black pigment in the coat is reduced on this background and is described as sepia, reddish-brown or slate-black
• yellow coat pigment in hair behind the ears, surrounding the mammae, and in the perineum is slightly diluted


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/06/2026
MGI 6.24
The Jackson Laboratory