Phenotypes Associated with This Genotype

Genotype
MGI:4360980

• Allelic Composition: Gt(ROSA)26Sor^{tm1(Wnk1)Clhu}/Gt(ROSA)26Sor⁺; Wnk1^{Gt(OST38262)Lex}/Wnk1^{Gt(OST38262)Lex}; Tg(Tek-cre)12Flv/0
• Genetic Background: involves: 129S5/SvEvBrd * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:152906 )

• all but one, died within 1 day of birth

• however, the early lethality seen in single Wnk1 homozygotes does not occur

cardiovascular system

cardiovascular system phenotype ( J:152906 )

N • unlike single Wnk1 homozygotes, heart morphology is grossly normal at E15.5

embryo

abnormal embryo development ( J:152906 )

• the incidence of abnormal embryos is increased compared to controls indicating only a partial rescue