Analysis Tools
mortality/aging
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• all mice die within the first day of birth
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vision/eye
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• mice exhibit eye morphology defects
• however, lens thickness is normal
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• reduced
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• 58% of mutant mice exhibit ciliary body coloboma
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• at E18.5, 99% of mutant mice exhibit ventral iris coloboma
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• the corneal stroma lacks collagen staining unlike in wild-type mice
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• shallow anterior chamber
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craniofacial
hearing/vestibular/ear
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• at E18.5
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embryo
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• at E15.5, neural crest cell proliferation is reduced compared to in wild-type mice
• however, neural crest cell migration into the periocular mesenchyme at E11.5 and levels of apoptosis are normal
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digestive/alimentary system
cellular
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• at E15.5, neural crest cell proliferation is reduced compared to in wild-type mice
• however, neural crest cell migration into the periocular mesenchyme at E11.5 and levels of apoptosis are normal
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growth/size/body
