Phenotypes for Aplp2 App Tg(Nes-cre)1Kln MGI:4359070 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Aplp2^tm1Dbo/Aplp2^tm1Dbo App^tm1.1Zhe/App^tm1.1Zhe Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aplp2^tm1Dbo mutation (1 available); any Aplp2 mutation (30 available)
App^tm1.1Zhe mutation (1 available); any App mutation (89 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuromuscular synapse morphology ( J:152457 )

• at E16.5, endplate band width and number are increased compared to in wild-type mice but not as severely as in Aplp2^tm1Dbo App^tm1.2Zhe double homozygotes

• at P0, presynaptic and postsynaptic terminal distribution is diffuse and nerve terminal sprouting occurs unlike in wild-type mice that is not as severe as in Aplp2^tm1Dbo App^tm1.2Zhe double homozygotes

abnormal miniature endplate potential ( J:152457 )

• reduced frequency

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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