Phenotypes Associated with This Genotype

Genotype
MGI:4356077

• Allelic Composition: Rfk^tm1.1Jcbr/Rfk^tm1.1Jcbr; Tg(Mx1-cre)1Cgn/?
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased macrophage nitric oxide production ( J:151999 )

• macrophges from mice where cre recombinase expression was induced produce less reactive NO in response to IFN-gamma, and to combinations of TNF/IFN-gamma, TNF/LPS or IFN-gamma/LPS

• similar results are obtained with TLR2, TLR3 and TLR9 agonists

homeostasis/metabolism

decreased macrophage nitric oxide production ( J:151999 )

• macrophges from mice where cre recombinase expression was induced produce less reactive NO in response to IFN-gamma, and to combinations of TNF/IFN-gamma, TNF/LPS or IFN-gamma/LPS

• similar results are obtained with TLR2, TLR3 and TLR9 agonists

hematopoietic system

decreased macrophage nitric oxide production ( J:151999 )

• macrophges from mice where cre recombinase expression was induced produce less reactive NO in response to IFN-gamma, and to combinations of TNF/IFN-gamma, TNF/LPS or IFN-gamma/LPS

• similar results are obtained with TLR2, TLR3 and TLR9 agonists