Phenotypes for Cdkn2a Kras Tg(Pdx1-cre)89.1Dam MGI:4355874 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Cdkn2a^tm4Rdp/Cdkn2a^tm4Rdp Kras^tm4Tyj/Kras^tm4Tyj Tg(Pdx1-cre)89.1Dam/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm4Rdp mutation (0 available); any Cdkn2a mutation (59 available)
Kras^tm4Tyj mutation (11 available); any Kras mutation (69 available)
Tg(Pdx1-cre)89.1Dam mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Pancreatic tumors in Kras^tm4Tyj/Kras^tm4Tyj Trim33^tm1Los/Trim33^tm1Los Tg(Pdx1-cre)89.1Dam/0 and Kras^tm4Tyj/Kras^tm4Tyj Cdkn2a^tm4Rdp/Cdkn2a^tm4Rdp Tg(Pdx1-cre)89.1Dam/0 mice

endocrine/exocrine glands

increased pancreas tumor incidence ( J:151781 )

• mice develop invasive pancreatic masses that are firm and homogeneous unlike in wild-type mice

pancreas cyst ( J:151781 )

neoplasm

increased pancreas tumor incidence ( J:151781 )

• mice develop invasive pancreatic masses that are firm and homogeneous unlike in wild-type mice

homeostasis/metabolism

abnormal metabolism ( J:151781 )

• PET scans detected abnormal metabolic activity in the abdomen unlike in wild-type mice

growth/size/body

pancreas cyst ( J:151781 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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