Phenotypes for Trp53 Trp63 MGI:4355557 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Trp53^tm1Tyj/Trp53^tm1Tyj Trp63^tm1.1Elrf/Trp63^tm1.1Elrf
Genetic Background	either: (involves: 129S2/SvPas * C57BL/6 * FVB/N) or (involves: 129S2/SvPas * 129S4/SvJae * 129S6/SvEvTac * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (232 available)
Trp63^tm1.1Elrf mutation (0 available); any Trp63 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

early cellular replicative senescence ( J:151638 )

• skin-derived precursors isolated from 1 month old mice exhibit increased staining for a marker of senescence and decreased apoptosis compared with wild-type and Trp63^tm1.1Elrf cells

integument

abnormal skin physiology ( J:151638 )

• after 8 days in culture, epidermal cells form fewer proliferating colonies than wild-type cells but more than Trp63^tm1.1Elrf cells

• after 20 days in culture, epidermal cells fail to form proliferating colonies unlike similarly treated wild-type cells

• skin-derived precursors isolated from 1 month old mice exhibit increased staining for a marker of senescence and decreased apoptosis compared with wild-type and Trp63^tm1.1Elrf cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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