Trp63^tm1.1Elrf
Targeted Allele Detail

Summary

• Symbol: Trp63^tm1.1Elrf
• Name: transformation related protein 63; targeted mutation 1.1, Elsa R Flores
• MGI ID: MGI:4355528
• Synonyms: TAp63^-
• Gene: Trp63 Location: Chr16:25502513-25710838 bp, + strand Genetic Position: Chr16, 17.37 cM
• Alliance: Trp63^tm1.1Elrf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:151638
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Modified isoform(s), Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted into intron 1 and an FRT site flanked neomycin resistance gene cassette and loxP site were inserted into intron 2. Exon 2, used for the TA isoforms, and the neo cassette were deleted through cre-mediated recombination. The absence of protein expression was confirmed by western blot analysis on keratinocyte extracts. This allele specifically knocks out the TA (trans activation domain) isoforms and leaves the deltaN isoform intact. (J:151638)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Trp63^tm1.1Elrf

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp63 Mutation: 60 strains or lines available

References

• Original: J:151638 Su X, et al., TAp63 prevents premature aging by promoting adult stem cell maintenance. Cell Stem Cell. 2009 Jul 2;5(1):64-75
• All: 14 reference(s)