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Phenotypes Associated with This Genotype
Genotype
MGI:4353812
Allelic
Composition
Plcb1tm1Hssh/Plcb1tm1Hssh
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plcb1tm1Hssh mutation (0 available); any Plcb1 mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• in a Morris water maze, standard housed and environmentally enriched mice fail to exhibit a preference for the target quadrant unlike similarly treated wild-type mice
• in a Morris water maze, standard housed exhibit decreased frequency of crossing over the platform and increased latency compared with wild-type mice
• mice in standard housing exhibit decreased startle reflex compared with wild-type mice in standard housing
• environmental enrichment fails to decrease startle reflex as in similarly treated wild-type mice
• however, clozapine attenuates startle reflex as in wild-type mice
• mice in standard housing exhibit hypoactivity compared with wild-type mice in standard housing
• however, mice exposed to environmental enrichment exhibit normal activity levels

nervous system
• mice in standard housing exhibit decreased prepulse inhibition compared with wild-type mice in standard housing
• however, environmental enrichment or treatment with clozapine rescue prepulse inhibition deficit

Mouse Models of Human Disease
OMIM ID Ref(s)
Schizophrenia; SCZD 181500 J:151070


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory