Mouse Genome Informatics
hm
    Plcb1tm1Hssh/Plcb1tm1Hssh
involves: 129/Sv * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
behavior/neurological
• in a Morris water maze, standard housed and environmentally enriched mice fail to exhibit a preference for the target quadrant unlike similarly treated wild-type mice
• in a Morris water maze, standard housed exhibit decreased frequency of crossing over the platform and increased latency compared with wild-type mice
• mice in standard housing exhibit decreased startle reflex compared with wild-type mice in standard housing
• environmental enrichment fails to decrease startle reflex as in similarly treated wild-type mice
• however, clozapine attenuates startle reflex as in wild-type mice
• mice in standard housing exhibit hypoactivity compared with wild-type mice in standard housing
• however, mice exposed to environmental enrichment exhibit normal activity levels

nervous system
• mice in standard housing exhibit decreased prepulse inhibition compared with wild-type mice in standard housing
• however, environmental enrichment or treatment with clozapine rescue prepulse inhibition deficit

Mouse Models of Human Disease
OMIM IDRef(s)
Schizophrenia; SCZD 181500 J:151070