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Phenotypes Associated with This Genotype
Genotype
MGI:4352856
Allelic
Composition
Pbx1tm1Mlc/Pbx1tm3.1Mlc
Tg(Mx1-cre)1Cgn/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pbx1tm1Mlc mutation (0 available); any Pbx1 mutation (38 available)
Pbx1tm3.1Mlc mutation (1 available); any Pbx1 mutation (38 available)
Tg(Mx1-cre)1Cgn mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• defects in the stem cell compartment are identical to mice heterozygous for Pbx1tm1Mlc and Pbx1tm3.1Mlc and carrying Tg(Tek-cre)1Ywa
• reduction in the number of common lymphoid progenitor cells
• assays indicate that long term hematopoietic stem cells are impaired in self renewal
• significant reduction in the number of long term hematopoietic stem cells


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory