Phenotypes Associated with This Genotype

Genotype
MGI:3852545

• Allelic Composition: Bmi1^tm1Brn/Bmi1^tm1Brn; Rnf2^tm1Mvl/Rnf2⁺
• Genetic Background: involves: 129/Ola * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:82399 )

• mutants die at 4-5 weeks of age, earlier than single homozygous Bmi1 mutants

growth/size/body

decreased body size ( J:82399 )

decreased body weight ( J:82399 )

postnatal growth retardation ( J:82399 )

• delay in postnatal development at P10, from which point onward, growth ceases almost entirely

behavior/neurological

impaired coordination ( J:82399 )

• severe lack of coordination

abnormal gait ( J:82399 )

• mutants exhibit a more abnormal gait than single homozygous Bmi1 mutants impaired coordination [MP:0001405

nervous system

gliosis ( J:82399 )

abnormal Purkinje cell dendrite morphology ( J:82399 )

• arborization of Purkinje cells in the molecular layer is different, with thicker and less branched dendrites

abnormal cerebellar granule layer morphology ( J:82399 )

• reduction in cellularity and size of the granular layer of the cerebellum

abnormal cerebellar molecular layer ( J:82399 )

• reduction in cellularity and size of the molecular layer of the cerebellum

small cerebellum ( J:82399 )

skeleton

abnormal axial skeleton morphology ( J:82399 )

• mutants exhibit axial skeleton abnormalities in the cervical, thoracic, lumbar and sacral regions

cellular

gliosis ( J:82399 )