Phenotypes Associated with This Genotype

Genotype
MGI:3852062

• Allelic Composition: Tg(ACTA1-UCP3)1Clap/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:142293 )

• after 8 months on a high-fat diet, mice weight 15% less than similarly treated wild-type mice

decreased oxygen consumption ( J:142293 )

• when fed a high-fat diet for 4 months, mice exhibit reduced oxygen consumption compared with similarly treated Ucp3^tm1Rei homozygotes

improved glucose tolerance ( J:142293 )

• when fed a high-fat diet for 1 to 3 months, mice exhibit improved glucose tolerance compared with similarly treated wild-type mice

• however, glucose tolerance after 4 or 8 months on a high fat diet is the same as in similarly treated wild-type mice

increased insulin sensitivity ( J:142293 )

• after 3 and 4 months on a high-fat diet, mice exhibit increased insulin sensitivity compared with similarly treated wild-type mice

• however, after 8 months on a high-fat diet mice exhibit normal insulin sensitivity

abnormal metabolism ( J:142293 )

• when fed a high-fat diet for 8 months, mice exhibit a 20% lower metabolic efficiency than in similarly treated wild-type mice

adipose tissue

abnormal epididymal fat pad morphology ( J:142293 )

• 36% smaller than in Ucp3^tm1Rei when fed a high-fat diet for 8 months

growth/size/body

decreased susceptibility to diet-induced obesity ( J:142293 )

• after 8 months on a high-fat diet, mice weight 15% less than similarly treated wild-type mice