Phenotypes Associated with This Genotype

Genotype
MGI:3851991

• Allelic Composition: Stk11^tm1Mmt/Stk11⁺; Trp53^tm1Brd/Trp53^tm1Brd
• Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:107275 )

• mice by at 7 months

neoplasm

increased tumor incidence ( J:107275 )

• at 25 weeks, one mouse develops bladder tumor unlike wild-type mice

increased ovary tumor incidence ( J:107275 )

♀ • in two mice at 30 weeks

increased liver tumor incidence ( J:107275 )

• 12 mice develop hepatic nodular foci unlike in wild-type mice

increased hepatocellular carcinoma incidence ( J:107275 )

• between 25 and 30 weeks in one mouse

increased hamartoma incidence ( J:107275 )

• after 12 weeks, all mice develop gastric hamartomas unlike wild-type mice

liver/biliary system

abnormal hepatocyte morphology ( J:107275 )

• enlarged and dysplastic in nodules

increased liver tumor incidence ( J:107275 )

• 12 mice develop hepatic nodular foci unlike in wild-type mice

increased hepatocellular carcinoma incidence ( J:107275 )

• between 25 and 30 weeks in one mouse

reproductive system

increased ovary tumor incidence ( J:107275 )

♀ • in two mice at 30 weeks

endocrine/exocrine glands

increased ovary tumor incidence ( J:107275 )

♀ • in two mice at 30 weeks