Phenotypes for Fos MGI:3850715 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Fos^tm1Wag/Fos^{tm2(Fosl1)Wag}
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fos^tm1Wag mutation (0 available); any Fos mutation (42 available)
Fos^{tm2(Fosl1)Wag} mutation (0 available); any Fos mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

failure of tooth eruption ( J:65766 )

absent teeth ( J:65766 )

decreased osteoclast cell number ( J:65766 )

• absent

abnormal bone marrow cavity morphology ( J:65766 )

• absent

osteopetrosis ( J:65766 )

vision/eye

increased retina apoptosis ( J:65766 )

• mice exhibit increased light-induced retinal cell apoptosis compared with wild-type mice

craniofacial

failure of tooth eruption ( J:65766 )

absent teeth ( J:65766 )

growth/size/body

failure of tooth eruption ( J:65766 )

absent teeth ( J:65766 )

decreased body size ( J:65766 )

• at 6 weeks

immune system

decreased osteoclast cell number ( J:65766 )

• absent

hematopoietic system

decreased osteoclast cell number ( J:65766 )

• absent

cellular

increased retina apoptosis ( J:65766 )

• mice exhibit increased light-induced retinal cell apoptosis compared with wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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