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Phenotypes Associated with This Genotype
Genotype
MGI:3850221
Allelic
Composition
Errfi1tm1Jwj/Errfi1tm1Jwj
Pgrtm2(cre)Lyd/Pgr+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Errfi1tm1Jwj mutation (0 available); any Errfi1 mutation (18 available)
Pgrtm2(cre)Lyd mutation (0 available); any Pgr mutation (73 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• E2-treated, ovariectomized mice develop endometrial cancer unlike similarly treated Errfi1tm1Jwj homozygotes
• however, ovariectomized mice treated with E2 and P4 do not develop endometrial cancer
• neoplastic endometrial glands invade adjacent structures such as the colon, pancreas, and skeletal muscle
• mice exhibit an increase in the ratio of gland to stroma compared to in Errfi1tm1Jwj homozygotes
• however, the myometrium is not enlarged
• the number of endometrial glands is increased compared to in Errfi1tm1Jwj homozygotes due to increased proliferation
• ovariectomized mice treated with E2 and P4 exhibit increased vascularization compared to in similarly treated Errfi1tm1Jwj homozygotes
• mice develop endometrial hyperplasia
• at 5 months, uterine wet weight is increased compared to in Errfi1tm1Jwj homozygotes
• after 3 months, ovectamized mice treated with E2 and P4 exhibit increased uterus weight compared to in similarly treated Errfi1tm1Jwj homozygotes
• despite normal oocyte numbers and uterine environment, female mice are infertile

neoplasm
• E2-treated, ovariectomized mice develop endometrial cancer unlike similarly treated Errfi1tm1Jwj homozygotes
• however, ovariectomized mice treated with E2 and P4 do not develop endometrial cancer
• neoplastic endometrial glands invade adjacent structures such as the colon, pancreas, and skeletal muscle

endocrine/exocrine glands
• the number of endometrial glands is increased compared to in Errfi1tm1Jwj homozygotes due to increased proliferation
• ovariectomized mice treated with E2 and P4 exhibit increased vascularization compared to in similarly treated Errfi1tm1Jwj homozygotes

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
endometrial cancer DOID:1380 OMIM:608089
J:150007


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory