Mouse Genome Informatics
cn
    Errfi1tm1Jwj/Errfi1tm1Jwj
Pgrtm2(cre)Lyd/Pgr+

involves: 129S1/Sv * 129X1/SvJ
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• mice exhibit an increase in the ratio of gland to stroma compared to in Errfi1tm1Jwj homozygotes
• however, the myometrium is not enlarged
• the number of endometrial glands is increased compared to in Errfi1tm1Jwj homozygotes due to increased proliferation
• ovariectomized mice treated with E2 and P4 exhibit increased vascularization compared to in similarly treated Errfi1tm1Jwj homozygotes
• mice develop endometrial hyperplasia
• at 5 months, uterine wet weight is increased compared to in Errfi1tm1Jwj homozygotes
• after 3 months, ovectamized mice treated with E2 and P4 exhibit increased uterus weight compared to in similarly treated Errfi1tm1Jwj homozygotes
• despite normal oocyte numbers and uterine environment, female mice are infertile

tumorigenesis
• E2-treated, ovariectomized mice develop endometrial cancer unlike similarly treated Errfi1tm1Jwj homozygotes
• however, ovariectomized mice treated with E2 and P4 do not develop endometrial cancer
• neoplastic endometrial glands invade adjacent structures such as the colon, pancreas, and skeletal muscle

endocrine/exocrine glands
• the number of endometrial glands is increased compared to in Errfi1tm1Jwj homozygotes due to increased proliferation
• ovariectomized mice treated with E2 and P4 exhibit increased vascularization compared to in similarly treated Errfi1tm1Jwj homozygotes

Mouse Models of Human Disease
OMIM IDRef(s)
Endometrial Cancer 608089 J:150007