Mouse Genome Informatics
cn
    Errfi1tm1Jwj/Errfi1tm1Jwj
Pgrtm2(cre)Lyd/Pgr+

involves: 129S1/Sv * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
reproductive system
• mice exhibit an increase in the ratio of gland to stroma compared to in Errfi1tm1Jwj homozygotes (J:150007)
• however, the myometrium is not enlarged (J:150007)
• the number of endometrial glands is increased compared to in Errfi1tm1Jwj homozygotes due to increased proliferation (J:150007)
• ovariectomized mice treated with E2 and P4 exhibit increased vascularization compared to in similarly treated Errfi1tm1Jwj homozygotes (J:150007)
• mice develop endometrial hyperplasia (J:150007)
• after 3 months, ovectamized mice treated with E2 and P4 exhibit increased uterus weight compared to in similarly treated Errfi1tm1Jwj homozygotes (J:150007)
• at 5 months, uterine wet weight is increased compared to in Errfi1tm1Jwj homozygotes (J:150007)
• ovectamized mice treated with E2 or E2 and P4 exhibit increased uterus weight compared to in similarly treated Errfi1tm1Jwj homozygotes (J:150007)
• despite normal oocyte numbers and uterine environment, female mice are infertile (J:150007)

tumorigenesis
• E2-treated, ovariectomized mice develop endometrial cancer unlike similarly treated Errfi1tm1Jwj homozygotes (J:150007)
• however, ovariectomized mice treated with E2 and P4 do not develop endometrial cancer (J:150007)
• neoplastic endometrial glands invade adjacent structures such as the colon, pancreas, and skeletal muscle (J:150007)

Mouse Models of Human Disease
OMIM IDRef(s)
Endometrial Cancer 608089 J:150007