Phenotypes Associated with This Genotype

Genotype
MGI:3849178

• Allelic Composition: Trp53^tm1Elee/Trp53^tm1Tyj; Tg(GFAP-cre)25Mes/0
• Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:149662 )

• all mice die prior to 500 days

behavior/neurological

tremors ( J:149662 )

• 85% of mice

ataxia ( J:149662 )

• 85% of mice

impaired balance ( J:149662 )

• 85% of mice

seizures ( J:149662 )

• 85% of mice

neoplasm

increased medulloblastoma incidence ( J:149662 )

• 90% of mice develop medulloblastomas

increased sarcoma incidence ( J:149662 )

• mice develop tumors outside of the central nervous system consisting of soft-tissue sarcomas

increased glioma incidence ( J:149662 )

• 90% of mice develop malignant gliomas with astrocytic characteristics

• 40% of high-grade astrocytic gliomas exhibit necrosis, pseudopalisading tumors cells, high degree of nuclear atypia, and microvascular proliferation similar to human glioblastoma multiforme

• tumors are relatively heterogeneous histological and in lineage marker expression

nervous system

nervous system phenotype ( J:149662 )

N • at 2 months of age, brain cells in the subventricular zone and progenitor cells exhibit normal growth rates

seizures ( J:149662 )

• 85% of mice

increased medulloblastoma incidence ( J:149662 )

• 90% of mice develop medulloblastomas

increased glioma incidence ( J:149662 )

• 90% of mice develop malignant gliomas with astrocytic characteristics

• 40% of high-grade astrocytic gliomas exhibit necrosis, pseudopalisading tumors cells, high degree of nuclear atypia, and microvascular proliferation similar to human glioblastoma multiforme

• tumors are relatively heterogeneous histological and in lineage marker expression

increased brain size ( J:149662 )

• in mice with neurological defects

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
glioblastoma		DOID:3068		J:149662